阿莫西林克拉维酸钾颗粒治疗急性胃肠炎的临床疗效
Clinical Efficacy of Amoxicillin and Clavulanate Potassium Granules in the Treatment of Acute Gastroenteritis
桂小明1
作者信息
- 1. 金溪县中医院消化内科,江西 金溪 344800
- 折叠
摘要
目的 观察阿莫西林克拉维酸钾颗粒治疗急性胃肠炎的临床疗效.方法 采用随机数字表法将 2021 年 1 月-2023 年 3 月我院诊治的 62 例急性胃肠炎患者分为对照组(n=31)和观察组(n=31).对照组采用阿奇霉素治疗,观察组采用阿莫西林克拉维酸钾颗粒治疗,比较两组临床疗效、临床症状(腹痛、腹泻、呕吐)消失时间、炎症指标因子[C 反应蛋白(CRP)、白细胞计数(WBC)]、肠胃功能分级情况以及不良反应发生率.结果 与对照组治疗总有效率(80.65%)比较,观察组治疗总有效率(93.55%)更高(P＜0.05);与对照组比较,观察组腹痛、腹泻、呕吐消失时间更短(P＜0.05);与治疗前比较,两组治疗后 CRP、WBC 均降低,且与对照组比较,观察组 CRP、WBC 更低(P＜0.05);与对照组比较,观察组肠胃功能 AGIⅠ级占比更大,AGIⅡ级、AGIⅢ级占比更小(P＜0.05);与对照组比较,观察组不良反应发生率更低(P＜0.05).结论 阿莫西林克拉维酸钾颗粒治疗急性胃肠炎的效果理想,可缩短临床症状消失时间,降低炎症因子水平,促进肠胃功能恢复,且可降低不良反应发生率.
Abstract
Objective To observe the clinical efficacy of amoxicillin and clavulanate potassium granules in the treatment of acute gastroenteritis.Methods Using the random number table method,62 acute gastroenteritis patients who diagnosed and treated in our hospital from January 2021 to March 2023 were selected as the research objects and divided into control group(n=31)and observation group(n=31).In the control group,patients were treated with azithromycin,while in the observation group,patients were treated with amoxicillin and clavulanate potassium granules.The clinical efficacy,disappearance time of clinical symptoms(abdominal pain,diarrhea,vomiting),inflammatory index factors[C-reactive protein(CRP),white blood cell count(WBC)],gastrointestinal function grading and incidence of adverse reactions were compared between the two groups.Results The observation group(93.55%)had higher the total effective rate of treatment than that in the control group(80.65%)(P＜0.05).Compared with the control group,the observation group had lower disappearance time of abdominal pain,diarrhea and vomiting(P＜0.05).Compared with before treatment,CRP and WBC in the two groups were decreased after treatment,and compared with the control group,the observation group had lower CRP and WBC levels(P＜0.05).Compared with the control group,the observation group had higher the proportion of gastrointestinal function AGI grade Ⅰ,and lower the proportion of AGI grade Ⅱ and AGI grade Ⅲ(P＜0.05).The observation group(6.45%)had lower the incidence of adverse reactions than that in the control group(19.35%)(P＜0.05).Conclusion Amoxicillin and clavulanate potassium granules have an ideal effect in the treatment of acute gastroenteritis,which can shorten the disappearance time of clinical symptoms,reduce the level of inflammatory factors,promote the recovery of gastrointestinal function,and reduce the incidence of adverse reactions.
关键词
阿莫西林克拉维酸钾颗粒/急性胃肠炎/C反应蛋白/肠胃功能分级Key words
Amoxicillin and clavulanate potassium granules/Acute gastroenteritis/C-reactive protein/Gastrointestinal function classification引用本文复制引用
出版年
2024
国家科技期刊平台
NSTL
万方数据