首页|中药活性肽的制备、分离纯化及鉴定研究进展

中药活性肽的制备、分离纯化及鉴定研究进展

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近年来研究发现,来源于水蛭、土鳖虫、蜈蚣等中药的活性肽具有显著抗凝血、调节血脂、抗肿瘤等药理活性.活性肽组分结构及化学性质接近,选用适宜的制备分离及鉴定方法以获取中药活性肽是研究的关键.然而相对于食品、水产等行业,中药活性肽分离纯化及鉴定的研究相对较少.为此,本文综述近年来中药活性肽制备分离纯化及鉴定相关方法,阐述其原理及特点,以期为中药活性肽的开发和应用提供参考.
Research Progress on Preparation,Separation,Purification and Identification of Active Peptides from Traditional Chinese Medicine
In recent years,studies have found that active peptides derived from leech,eupolyphaga,centipede and other traditional Chinese medicines have significant anticoagulant,blood lipid regulation,anti-tumor and other pharmacological activities.The structure and chemical properties of active peptides are similar.The key to the study is to select appropriate preparation,separation and identification methods to obtain active peptides from traditional Chinese medicine.However,compared with food,aquaculture and other industries,there are relatively few studies on the separation,purification and identification of active peptides from traditional Chinese medicine.Therefore,this paper reviews the methods of preparation,separation,purification and identification of active peptides from traditional Chinese medicine in recent years,and expounds its principles and characteristics,in order to provide reference for the development and application of active peptides from traditional Chinese medicine.

Active peptides from traditional Chinese medicineSeparation and purificationColumn chromatographyMembrane separationMass spectrumStructural identification

刘长龙、张昊皓、杨天硕、李云霄

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山东中医药大学第二附属医院制剂中心,山东 济南 250000

山东第一医科大学附属内分泌与代谢病医院药剂科,山东 济南 250001

中药活性肽 分离纯化 柱层析 膜分离 质谱 结构鉴定

2024

医学信息
国家卫生部信息化管理领导小组 中国电子学会中国医药信息学分会 陕西文博生物信息工程研究所

医学信息

影响因子:0.161
ISSN:1006-1959
年,卷(期):2024.37(23)