Preventive Effect of Cefazolin Sodium Combined with Metronidazole on Incision Infection After Laparoscopic Myomectomy in Patients with Uterine Fibroids
Objective To explore the preventive effect of cefazolin sodium combined with metronidazole on incision infection after laparoscopic myomectomy in patients with uterine fibroids.Methods From July 2021 to June 2023,60 patients with laparoscopic myomectomy admitted to our hospital were selected as the research objects.According to the random number table method,all patients were divided into control group and study group,with 30 patients in each group.The control group was treated with metronidazole,and the study group was treated with cefazolin sodium combined with metronidazole.The serum oxidative stress levels[malondialdehyde(MDA),superoxide dismutase(SOD),nitric oxide(NO),plasma endothelin-1(ET-1)],incision growth status(incision granulation tissue hyperplasia degree,incision exudation range),serum inflammatory factor levels[tumor necrosis factor(TNF)-α,C-reactive protein(CRP),interleukin(IL)-8]were compared between the two groups.Results After treatment,the levels of MDA and ET-1 in the two groups decreased,and the levels of SOD and NO increased,while the levels of MDA and ET-1 in the study group were lower than those in the control group,and the levels of SOD and NO were higher than those in the control group(P<0.05).After treatment,the scores of granulation tissue hyperplasia and incision exudation range in the two groups were lower than those before treatment,and the scores of granulation tissue hyperplasia and incision exudation range in the study group were lower than those in the control group(P<0.05).After treatment,the levels of TNF-α,CRP and IL-8 in the two groups were lower than those before treatment,and the levels of TNF-α,CRP and IL-8 in the study group were lower than those in the control group(P<0.05).Conclusion Cefazolin sodium combined with metronidazole for anti-infection treatment after laparoscopic myomectomy in patients with uterine fibroids can promote the healing of postoperative infection incision,reduce the level of serum inflammatory factors,and improve the body's oxidative stress response,which is worthy of clinical application.
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