医学新知2024,Vol.34Issue(3) :276-281.DOI:10.12173/j.issn.1004-5511.202312022

糖尿病合并尿路感染患者酮症酸中毒的影响因素分析

Factors influencing ketoacidosis in patients with diabetes and urinary tract infection

刘文 向世强 龚雅琪 袁华兵 徐金娥
医学新知2024,Vol.34Issue(3) :276-281.DOI:10.12173/j.issn.1004-5511.202312022

糖尿病合并尿路感染患者酮症酸中毒的影响因素分析

Factors influencing ketoacidosis in patients with diabetes and urinary tract infection

刘文 1向世强 2龚雅琪 3袁华兵 3徐金娥3
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作者信息

  • 1. 武汉科技大学医学院(武汉 430065);天门市第一人民医院内分泌科(湖北天门 431700)
  • 2. 武汉科技大学医学院(武汉 430065)
  • 3. 天门市第一人民医院内分泌科(湖北天门 431700)
  • 折叠

摘要

目的 探讨 2 型糖尿病合并尿路感染患者糖尿病酮症酸中毒(diabetic ketoacidosis,DKA)的临床特点及影响因素,为DKA预防及早期干预提供参考.方法 回顾性收集 2022 年 1 月至 2023 年 9 月天门市第一人民医院收治的糖尿病合并尿路感染患者的病历资料,根据住院期间是否发生DKA分为DKA组和非DKA组,比较分析DKA发生的影响因素.结果 共纳入 137 例患者,其中DKA组 35 例、非DKA组 102例,DKA发生率为 25.55%,两组患者在年龄以及空腹血糖、糖化血红蛋白(HbA1c)、血清降钙素原(PCT)、尿白细胞水平方面差异均具有统计学意义(P<0.05).多因素Logistic回归分析显示,年龄≥60 岁[OR=2.369,95%CI(1.013,5.541)]、血清PCT≥0.5 ng·L-1[OR=3.234,95%CI(1.215,8.609)]、HbA1c≥7%[OR=2.958,95%CI(1.130,7.743)]是糖尿病合并尿路感染者发生DKA的危险因素.结论 年龄≥60 岁、血清PCT≥0.5 ng·L-1 及HbA1c≥7%是糖尿病合并尿路感染者发生DKA的独立危险因素,临床医生应及时识别,尽早预防.

Abstract

Objective To investigate the clinical characteristics and influencing factors of diabetic ketoacidosis(DKA)patients with diabetes mellitus type 2 complicated with urinary tract infection,and to provide reference for the prevention and early intervention of DKA.Methods The medical records of patients with diabetes mellitus complicated with urinary tract infection admitted to the First People's Hospital of Tianmen in Hubei Province from January 2022 to September 2023 were retrospectively collected,and the patients were divided into DKA group and non-DKA group according to whether DKA occurred during hospitalization,and the influencing factors of DKA were compared and analyzed.Results A total of 137 patients were collected,including 35 cases in the DKA group and 102 cases in the non-DKA group,the incidence rate of DKA is 25.55%.There were significant differences in age,fasting blood glucose levels,glycosylated hemoglobin(HbA1c),serum procalcitonin(PCT)and urinary leukocyte levels between the two groups(P<0.05).Multivariate Logistic regression analysis showed that age≥60 years[OR=2.369,95%CI(1.013,5.541)],blood PCT≥0.5 ng·L-1[OR=3.234,95%CI(1.215,8.609)]and HbA1c≥7%[OR=2.958,95%CI(1.130,7.743)]were risk factors for DKA in patients with diabetes mellitus and urinary tract infection.Conclusion Age≥60 years,blood PCT≥0.5 ng·L-1,and HbA1c≥7%were independent risk factors for DKA in patients with diabetes mellitus and urinary tract infection.Clinicians should identify it in time for early prevention.

关键词

糖尿病/酮症酸中毒/尿路感染/危险因素

Key words

Diabetes mellitus/Ketoacidosis/Urinary tract infections/Risk factors

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基金项目

湖北省自然科学基金(2022CFB514)

出版年

2024
医学新知
武汉大学中南医院,中国农工民主党湖北省委医药卫生工作委员会

医学新知

CSTPCD
影响因子:0.243
ISSN:1004-5511
被引量1
参考文献量29
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