Spinal cord injury(SCI)is a disease that profoundly impacts the central nervous system,with oxidative stress playing a crucial role in its secondary damage.This article provides a comprehensive review of the role of oxidative stress in SCI,its primary signaling pathways,and current treatment methods.It focuses particularly on the functions of pathways such as Nrf-2,PI3K/AKT,and TLR4/MyD88 in the regulation of oxidative stress and explores the potential of antioxidant therapies in alleviating SCI symptoms.This paper aims to offer insights for a deeper understanding of SCI and provide reference for optimizing treatment strategies.
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