Objective To study the factors influencing serum reversal in HIV-exposed children.Methods The general information,clinical data,and serum results of 49 cases of HIV-infected pregnant women and their children exposed to HIV were collected from the Shenzhen Third People's Hospital from January 2019 to December 2021.Results All 49 HIV-exposed children were tested negative for HIV nucleic acid at 48 h,6 weeks,and 3 months of age.The serum reversal rates at 12,18 and 21 months were 59.18％,93.87％and 100％,respectively.Whether the serum of HIV-exposed children was reversed at 12 months of age was not related to the maternal delivery,anti-retroviral therapy initiation time,nucleic acid test results,CD4+T lymphocyte count(P＞0.05).It was not related to children's sex,gestational age,birth weight,and the type of blocking drug used(P＞0.05).Conclusion No clear influencing factors were found for serum reversal in HIV-exposed 12-month-old children.The consistency between nucleic acid detection and final serum reversal was 100％.In order to exclude the possibility of HIV infection as soon as possible and reduce family concerns,three times of negative nucleic acid results before 3 months of age in HIV-exposed children may be considered as a substitute for serum reversal.
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