摘要
目的 探讨ABC-X模型护理干预联合奥马珠单抗对儿童中重度过敏性哮喘(allergic asthma,AA)的临床疗效及对家属负面情绪的影响.方法 前瞻性招募 2022年 1 月至 2023 年 1 月在新疆医科大学第一附属医院就诊的AA患儿及家属,根据随机数字表法,将AA患儿及家属分为ABC-X组(ABC-X模型护理干预联合奥马珠单抗)和常规组(常规护理联合奥马珠单抗).观察并比较两组干预前后患儿临床疗效、奥马珠单抗不良反应发生率、肺功能指标、免疫功能指标、炎性指标及家属负面情绪评分.结果 本研究共招募120对哮喘患儿及家属,每组各60对.干预前,两组在C-ACT评分、肺功能指标、免疫功能指标、炎性指标、SAS评分、SDS评分方面差异无统计学意义(P＞0.05).干预16周后,在AA患儿临床疗效和安全性方面,ABC-X组治疗总有效率和C-ACT评分均显著高于常规组(P＜0.05),且两组不良反应发生率差异无统计学意义(P＞0.05);在家属负面情绪方面,两组SAS和SDS评分均较干预前显著下降(P＜0.05),且干预后ABC-X组SAS和SDS评分显著低于常规组(P＜0.05);在肺功能和免疫功能方面,两组FEV1、FEV1/FVC、PEF、CD3、CD4和CD4/CD8均较干预前显著上升(P＜0.05),且干预后ABC-X组显著高于常规组(P＜0.05);在炎性指标方面,两组MIP-1α、MCP-1、IL-1β和IL-8 均较干预前显著下降(P＜0.05),且干预后ABC-X组显著低于常规组(P＜0.05).结论 ABC-X模型护理干预可促进奥马珠单抗治疗AA患儿的临床效果,改善肺功能和免疫功能,增强抗炎效应,缓解患儿家属负面情绪.
Abstract
Objective To explore the clinical efficacy of ABC-X model intervention combined with omalizumab on moderate to severe allergic asthma(AA)and negative emotions of family members.Methods AA children and their families from the First Affiliated Hospital of Xinjiang Medical University from January 2022 to January 2023 were prospectively recruited in the research.According to the random number table method,AA children and their families were divided into ABC-X group(ABC-X model care intervention combined with omalizumab)and routine group(usual care combined with omalizumab).Observe and compare clinical efficacy before and after intervention,incidence of adverse reactions to omalizumab,pulmonary function,immune function,inflammatory indicators,and negative emotions of family members.Results A total of 120 children with asthma and their families were recruited in the study,with 60 pairs in each group.Before the intervention,C-ACT scores,lung function,immune function,inflammatory indicators,SAS scores and SDS scores showed no statistically significant differences between the ABC-X and conventional groups(P>0.05).After 16 weeks of intervention,in terms of clinical efficacy and safety in children with AA,the total response rate and C-ACT rate in the ABC-X group were significantly higher than the conventional group after intervention(P<0.05),and the occurrence of adverse reactions were similar in both groups(P>0.05).In terms of family negative emotions,SAS and SDS scores decreased significantly compared with before intervention(P<0.05),and SAS and SDS scores in the ABC-X group were significantly lower than the conventional group after intervention after intervention(P<0.05).In terms of lung function and immune function,FEV1,FEV1/FVC,PEF,CD3,CD4 and CD4/CD8 were significantly higher than before intervention(P<0.05),and FEV1,FEV1/FVC,PEF,CD3,CD4 and CD4/CD8 were significantly higher than the conventional group(P<0.05).In terms of inflammatory indicators,MIP-1α,MCP-1,IL-1β and IL-8 were significantly decreased(P<0.05),and MIP-1α,MCP-1,IL-1β and IL-8 in the ABC-X group were significantly lower than those in the conventional group after intervention(P<0.05).Conclusion ABC-X model nursing intervention can promote the effect of omalizumab,improve lung function and immune function,enhance anti-inflammatory effect in children with moderate to severe AA.
基金项目
新疆维吾尔自治区自然科学基金(2019D01C310)
国家科技期刊平台
NSTL
万方数据