Glaucoma is the most common cause of irreversible blindness in the world,of which pathogenesis,such as autoimmune mechanism and inflammation theory,has been the focus of research in recent years.Interleukin(IL)is a key cytokine-mediated immunity,and may be involved in the pathogenesis of glaucoma.IL-1,IL-8 and IL-17,as the representative pro-inflammatory cytokines,are involved from the discharge of aqueous humor in the anterior segment to the loss of nerve cells in the posterior segment of the eye.As a pleiotropic cytokine,whether IL-6 plays a positive or negative role in glaucoma is still controversial.Anti-inflammatory factors such as IL-10,IL-4 and IL-13 can protect retinal ganglion cells.This paper reviews the literature on the relationship between IL and glaucoma in recent years,hoping to provide the theoretical basis for the follow-up study on the pathogenesis of glaucoma and the development of new drugs.
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