CD24在肿瘤微环境中的作用及治疗研究进展
Research progress on the role and treatment of CD24 in the tumor microenvironment
于欣静 1乔晓娟1
作者信息
- 1. 内蒙古医科大学附属医院肿瘤内科(呼和浩特 010030)
- 折叠
摘要
分化簇24(cluster of differentiation 24,CD24)是一种黏蛋白样磷脂酰肌醇锚定的表面蛋白,在大部分恶性肿瘤中高表达,通过多种机制促进肿瘤的发生及进展,并在肿瘤微环境中发挥重要作用,在体内外试验中已展现出较好的抗肿瘤治疗前景.本文综述了 CD24在肿瘤微环境中参与恶性肿瘤的生长、增殖、侵袭转移等方面的生物学行为,阐述以CD24为靶点的单克隆抗体、抗体偶联药物、嵌合抗原受体免疫疗法、纳米颗粒介导的药物递送等相关治疗策略,以期为CD24作为靶点的治疗提供参考.
Abstract
Cluster of differentiation 24(CD24)is a surface protein anchored by mucin-like phosphatidylinositol.It is highly expressed in most malignant tumors,promotes tumor occurrence and progression through various mechanisms,and plays an important role in the tumor microenvironment.CD24 has shown promising prospects for anti-tumor therapy in both in vitro and in vivo experiments.This article reviewed the role of CD24 in the tumor microenvironment in the proliferation,invasion and metastasis of malignant tumors,and describes the related therapeutic strategies of CD24-targeting monoclonal antibodies,antibody-drug conjugates,chimeric antigen receptor,and nanoparticle-mediated drug delivery,to provide reference for CD24-targeted therapy.
关键词
CD24/肿瘤微环境/恶性肿瘤Key words
CD24/Tumor microenvironment/Malignant tumors引用本文复制引用
基金项目
内蒙古自治区自然科学基金项目(2021MS08153)
内蒙古自治区高校青年科技英才项目(NJYT22011)
内蒙古自治区高等学校科学研究项目(NJZY21596)
内蒙古自治区卫生健康科技计划项目(202201295)
内蒙古医科大学科技百万工程项目(YKD2020KJBWLH039)
内蒙古医科大学"致远"人才计划善学人才项目(ZY0202022)
出版年
2024
国家科技期刊平台
NSTL
万方数据