摘要
目的 通过Meta分析了解脑卒中患者肌少症发生率,为脑卒中患者肌少症早识别、早干预提供循证依据.方法 计算机检索PubMed、Embase、Web of Science A The Cochrane Library、CHINAL、中国知网、万方、维普、中国生物医学文献数据库,检索从建库至2024年1月国内外公开发表的关于脑卒中患者肌少症发生率的相关文献.采用Stata 16.0软件进行Meta分析.结果 共纳入23篇文献,包括6 349例患者.Meta分析结果显示,脑卒中患者肌少症总体发生率为44.0％[95％CI(36.4％,51.6％)].亚组分析结果显示,中国、日本、韩国、美国脑卒中肌少症发生率分别为41.9％[95％CI(27.4％,56.5％)]、53.5％[95％CI(43.2％,63.8％)]、34.1％[95％CI(27.7％,40.4％)]、16.8％[95％CI(11.5％,22.2％)];不同诊断标准脑卒中肌少症发生率不尽相同,AWGS 最高[47.2％,95％CI(36.6％,57.7％)],其次为EWGSOP 2[46.2％,95％CI(31.7％,60.8％)];女性[51.7％,95％CI(43.1％,60.3％)]肌少症发生率高于男性[40.8％,95％CI(32.2％,49.5％)];不同卒中类型肌少症发生率也不尽相同,出血性脑卒中最高[48.0％,95％CI(38.3％,57.8％)];年龄≥ 60岁脑卒中患者肌少症发生率显著高于年龄＜60 岁者,分别为 56.6％[95％CI(37.6％,75.7％)]、25.0％[95％CI(6.5％,43.4％)].Egger's检验P＞0.05,提示研究不存在发表偏倚.结论 脑卒中患者肌少症发生率较高,需引起重视,并建议对女性、出血性脑卒中、年龄大于60岁的脑卒中患者及时进行肌少症的筛查和评估.
Abstract
Objective To understand the incidence of sarcopenia in stroke patients through Meta-analysis,and to provide the evidence-based basis for early identification and intervention of sarcopenia in stroke patients.Methods PubMed,Embase,Web of Science,The Cochrane Library,CHINAL,CNKI,WanFang,VIP and SinoMed databases were searched for relevant literature on the incidence of sarcopenia in stroke patients published from inception to January 2024.Meta-analysis of incidence was performed using Stata 16.0.Results 23 articles were included,including 6,349 patients.The Meta-analysis showed that the overall incidence of sarcopenia in stroke patients was 44.0％[95％CI(36.4％,51.6％)].The results of the subgroup analysis showed that the incidence of stroke sarcopenia in China,Japan,Korea,and the United States was 41.9％[95％CI(27.4％,56.5％)],53.5％[95％CI(43.2％,63.8％)],34.1％[95％CI(27.7％,40.4％)],and 16.8％[95％CI(11.5％,22.2％)],respectively.The incidence of stroke sarcopenia varied by diagnostic criteria,with AWGS being the highest as 47.2％[95％CI(36.6％,57.7％)],followed by EWGSOP 2[46.2％,95％CI(31.7％,60.8％)].The incidence of sarcopenia was higher in females[51.7％,95％CI(43.1％,60.3％)]than in males[40.8％,95％CI(32.2％,49.5％)].The incidence of sarcopenia varied by stroke type,with hemorrhagic stroke being the highest as 48.0％[95％CI(38.3％,57.8％).The incidence of sarcopenia was significantly higher in stroke patients aged＞60 years[56.6％,95％CI(37.6％,75.7％)]than in those aged＜60 years[25.0％,95％CI(6.5％,43.4％)].The Egger's test was P＞0.05,suggesting the study was free from publication bias.Conclusion The high incidence of sarcopenia in stroke patients requires attention and suggests timely screening and evaluation for sarcopenia in women,hemorrhagic stroke,and stroke patients older than 60 years of age.
维普
万方数据