目的 分析1990-2021年中国良性前列腺增生(benign prostatic hyperplasia,BPH)疾病负担及变化趋势.方法 根据2021年全球疾病负担研究的数据,分析1990-2021年中国BPH的发病、患病和伤残调整寿命年(disability-adjusted life year,DALY)及其变化趋势.通过计算年龄标准化率的年估计变化百分比(estimated annual percentage changes,EAPC)来评估疾病负担的时间趋势.通过社会人口指数(social demographic index,SDI)来对比分析中国BPH疾病负担随年份发展的变化趋势.结果 2021年中国BPH的发病例数为324.45万例,年龄标准化发病率为229.14/10万;患病例数为2 311.12万例,年龄标准化患病率为2 315.23/10万;DALY为46.02万人年,年龄标准化DALY率为45.84/10万.2021年中国BPH的发病率、患病率与DALY率随年龄的增长呈先上升后下降的趋势,分别在75～79岁和80～84岁年龄段达到高峰.1990-2021年中国BPH的年龄标准化发病率[EAPC=-0.21,95％CI(-0.36,-0.06)]、年龄标准化患病率[EAPC=-0.24,95％CI(-0.41,-0.07)]和年龄标准化 DALYs 率[EAPC=-0.25,95％CI(-0.43,-0.09)]保持下降趋势,而发病例数(122.16％)、患病例数(132.50％)和DALYs(130.15％)均表现为上升趋势.1990-2021年期间中国BPH的年龄标准化发病率、年龄标准化患病率和年龄标准化DALYs率远高于高SDI国家.结论 我国BPH的疾病负担重,应增强对中老年男性的前列腺健康宣教,探索适用于我国国情的BPH疾病预防和控制体系,通过早发现、早干预延缓疾病进展以降低疾病负担.
Abstract
Objective To analysis disease burden and its change trend of benign prostatic hyperplasia(BPH)in China from 1990 to 2021.Methods Data from the Global Burden of Disease Study 2021(GBD 2021)database were obtained to analysis the incidence,prevalence,disability-adjusted life years(DALYs)of BPH in China from 1990 to 2021.Assessing temporal trends in the burden of disease by calculating estimated annual percentage changes(EAPC)in age standardised rates and comparative analysis of trends in the burden of BPH in China over time by social demographic index(SDI)were conducted.Results In 2021,the incident cases of BPH in China were 3.244 million,with age-standardized incidence rate(ASIR)of 229.14 per 100,000.The prevalent cases were 2.311 million,with age-standardized prevalence rate(ASPR)of 2,315.23 per 100,000.The number of DALYs were 460,200 person year,with age-standardized DALYs rate(ASDR)of 45.84 per 100,000.The incidence,prevalence and DALYs rates of BPH in China in 2021 initially increased with age and then decreased,peaking in the 75-79 and 80-84 age groups,respectively.The ASIR[EAPC=-0.21,95％CI(-0.36,-0.06)],ASPR[EAPC=-0.24,95％CI(-0.41,-0.07)],and ASDR[EAPC=-0.25,95％CI(-0.43,-0.09)]of BPH in China maintained a decreasing trend from 1990 to 2021,whereas the number of incident cases(122.16％),prevalent cases(132.50％),and DALYs(130.15％)showed an increasing trend.The ASIR,ASPR,and ASDR of BPH in China over the period 1990-2021 were much higher than those in high SDI countries.Conclusion The burden of BPH is high in China.Efforts should be made to enhance prostate health education for middle-aged and older men and to explore a BPH prevention and control system suitable for China's conditions.By promoting early detection and intervention,the progression of the disease can be delayed,reducing the overall disease burden.
关键词
良性前列腺增生/疾病负担/发病率/患病率/伤残调整寿命年
Key words
Benign prostatic hyperplasia/Disease burden/Incidence/Prevalence/Disability-adjusted life years
维普
万方数据