Effect of neutrophil/lymphocyte ratio on prognosis of perforating artery disease
Objective To investigate the risk factors affecting the poor prognosis of perforating artery disease(PAD).Methods 174 patients with acute PAD admitted to the Department of Neurology,Dushu Lake Hospital Affiliated to Soochow Universi-ty from September 2021 to May 2023 were retrospectively analyzed.According to the improved Rankin score(mRS)after 90 days,0-2 scores were good prognosis group,3-6 scores were poor prognosis group;logistic regression model was used to analyze the risk factors affecting the prognosis of patients with PAD.According to the intracranial arteries from which the blood supply arteries originated,the patients were divided into anterior circulation group(n=101)and posterior circulation group(n=73).The correlation between anteri-or and posterior circulation and poor prognosis was analyzed.Results Multi-factor logistic regression showed that the increase of age(OR=1.071,95%CI:1.012-1.133),the increase of NIHSS score on admission(OR=2.764,95%CI:1.868-4.089),diabetes history(OR = 3.301,95%CI:1.009-10.793)and increased neutrophil/lymphocyte ratio(NLR)(OR=2.601,95%CI:1.150-4.482)were risk factors for poor prognosis in PAD patients(P＜0.05).ROC curve results suggested that compared with increasing age and diabetes history,the increase of NIHSS score and NLR had greater AUC in predicting poor prognosis in PAD patients,and the o-verall sensitivity and specificity were higher,suggesting that their val-ue in predicting poor prognosis might be higher.The decrease of LYM and the increase of NLR in the anterior circulation group were significantly correlated with poor prognosis(P＜0.05),and the increase of NE,the decrease of LYM and the increase of NLR in the posterior circulation group were significantly correlated with poor prognosis(P＜0.05).Conclusion The increase of baseline NLR and NIHSS scores,advanced age and diabetes history may be independent risk factors for poor prognosis of PAD patients,and NLR can be used as a potential biological index to predict the prognosis of PAD patients.
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