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非免疫性胎儿水肿的临床特点与妊娠结局分析

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目的 探讨非免疫性胎儿水肿的一般临床资料、超声特点、妊娠合并症及新生儿结局.方法 收集 2016 年 1月至 2022 年 12 月在南京医科大学附属妇产医院产科分娩的 50 例非免疫性胎儿水肿(NIHF)患者(胎儿水肿组).并依据孕妇年龄、孕周等基本信息 1∶2 随机匹配的 100 例非胎儿水肿患者(对照组).对非免疫性胎儿水肿的危险因素、妊娠并发症、母儿结局等进行回顾性分析.结果 与对照组相比,胎儿水肿组的孕妇妊娠次数≥3、既往不良孕产史、初产妇比率显著高于对照组(P<0.01).典型胎儿水肿综合征16 例;皮肤水肿占58.00%,全身水肿、脐带水肿占16%,胸腔积液占14.00%,腹腔积液占 12.00%.胎儿水肿组的孕妇合并早产、妊娠期高血压疾病、羊水过多、脐带扭转、胎儿窘迫以及脐血流异常的发生率高于对照组(P<0.05).胎儿水肿组新生儿窒息发生率(包括轻度和重度)、新生儿分娩孕周以及出生体重小于对照组(P<0.001);但胎儿水肿组剖宫产率高于对照组(P<0.001).结论 对孕次≥3、既往不良孕产史等高危人群要加强监测,及时干预治疗.完善产前指导,提高产检质量,从而降低胎儿水肿的发生率,对提高人口出生质量具有重要意义.
Analysis of clinical characteristics and pregnancy outcomes of non-immune hydrops fetalis
Objective To investigate the general clinical data,ultrasound features,pregnancy complications and neonatal outcomes of non-immune hydrops fetalis(NIHF).Methods It was collected a total of 50 patients with non-immune fetal edema(fetal edema group)who gave birth in the Department of Obstetrics and Gynecology Hospital of Nanjing Medical University from January 2016 to December 2022.100 patients with non-fetal edema(control group)were randomly matched according to the basic information of pregnant women's age and gestational age 1∶2.The risk factors,pregnancy complications and maternal and infant outcomes of non-immune fetal edema were analyzed retrospectively.Results Compared with the control group,the number of pregnancies≥3,pre-vious adverse pregnancy history and the rate of primipara in the fetal edema group were significantly higher than those in the control group(P<0.01).16 cases of typical fetal edema syndrome;Skin edema accounted for 58.00%,whole body edema,umbilical cord e-dema accounted for 16%,pleural effusion accounted for 14.00%,abdominal effusion accounted for 12.00%.The incidence of preterm birth,hypertensive disease during pregnancy,hyperamniotic fluid,umbilical cord torsion,fetal distress and abnormal cord blood flow in the fetal edema group was higher than that in the control group(P<0.05).The incidence of neonatal asphyxia(including mild and severe),gestational weeks and birth weight of newborns in the fetal edema group were lower than those in the control group(P<0.001).However,the cesarean section rate in the fetal edema group was high-er than that in the control group(P<0.001).Conclusion It is necessary to strengthen monitoring,timely intervention and treatment for high-risk groups such as the number of pregnancies≥3 and previ-ous adverse pregnancy history.It is of great significance to improve the birth quality of population by improving the prenatal guidance and improving the quality of birth examination,so as to reduce the incidence of hydrops fetalis.

non-immune hydrops fetalisclinical characteristicspregnancy outcomes

申洁、季小红、刘岚

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210000 南京,南京医科大学附属妇产医院(南京市妇幼保健院) 产科

非免疫性胎儿水肿 临床特点 妊娠结局

江苏省妇幼保健协会科研项目

FYX202306

2024

医学研究生学报
南京军区南京总医院

医学研究生学报

CSTPCD北大核心
影响因子:1.652
ISSN:1008-8199
年,卷(期):2024.37(1)
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