Analysis of clinical characteristics and pregnancy outcomes of non-immune hydrops fetalis
Objective To investigate the general clinical data,ultrasound features,pregnancy complications and neonatal outcomes of non-immune hydrops fetalis(NIHF).Methods It was collected a total of 50 patients with non-immune fetal edema(fetal edema group)who gave birth in the Department of Obstetrics and Gynecology Hospital of Nanjing Medical University from January 2016 to December 2022.100 patients with non-fetal edema(control group)were randomly matched according to the basic information of pregnant women's age and gestational age 1∶2.The risk factors,pregnancy complications and maternal and infant outcomes of non-immune fetal edema were analyzed retrospectively.Results Compared with the control group,the number of pregnancies≥3,pre-vious adverse pregnancy history and the rate of primipara in the fetal edema group were significantly higher than those in the control group(P<0.01).16 cases of typical fetal edema syndrome;Skin edema accounted for 58.00%,whole body edema,umbilical cord e-dema accounted for 16%,pleural effusion accounted for 14.00%,abdominal effusion accounted for 12.00%.The incidence of preterm birth,hypertensive disease during pregnancy,hyperamniotic fluid,umbilical cord torsion,fetal distress and abnormal cord blood flow in the fetal edema group was higher than that in the control group(P<0.05).The incidence of neonatal asphyxia(including mild and severe),gestational weeks and birth weight of newborns in the fetal edema group were lower than those in the control group(P<0.001).However,the cesarean section rate in the fetal edema group was high-er than that in the control group(P<0.001).Conclusion It is necessary to strengthen monitoring,timely intervention and treatment for high-risk groups such as the number of pregnancies≥3 and previ-ous adverse pregnancy history.It is of great significance to improve the birth quality of population by improving the prenatal guidance and improving the quality of birth examination,so as to reduce the incidence of hydrops fetalis.