Study on esophageal motility and clinical characteristics in patients with systemic sclerosis
Objective To explore the clinical characteristics and influencing factors of esophageal function in patients with systemic sclerosis(SSc).Methods The clinical data of SSc patients who underwent high-resolution esophageal manometry(HREM)examination at the Gastrointestinal Motility Center of the First Affiliated Hospital of Nanjing Medical University from January 2016 to December 2022 were retrospectively analyzed.The correlation between its esophageal motility characteristics,clinical character-istics,and esophageal motility were analyzed.Results Among 29 patients with SSc,18 patients had esophageal symptoms,and dysphagia was the most common symptom(13/29,44.8%).Esophageal body motility disorders were the most common,especially aperistalsis and abnormal peristalsis.Acid reflux was positively correlated with absent peristalsis rate(APR)of esophageal body(rs= 0.497,P＜0.05).The number of involved systems outside the digestive tract was negatively correlated with the average distal contrac-tion integral(DCI),while positively correlated with APR(rs=-0.466 and 0.408,both P＜0.05).Erythrocyte sedimentation rate was negatively correlated with upper esophageal sphincter residual pressure and DCI(P＜0.05).Serum C3 and C4 levels were negatively correlated with APR(P＜0.05).Conclusion Patients with SSc are prone to abnormal esophageal motility and esophageal symp-toms,and esophageal dysfunction can occur in the absence of esophageal symptoms.The more systems SSc involves,the more severe the condition,and disease activity is more likely to be accompanied by esophageal dysfunction.
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万方数据
