Levels of serum ghrelin,C1q tumor necrosis factor related protein 3 and their relationship with poor prog-nosis in patients with spinal fracture complicated with spinal cord injury
Objective To explore the levels of serum ghrelin,C1q tumor necrosis factor related protein 3(CTRP3)and their relationship with poor prognosis in patients with spinal fracture complicated with spinal cord injury.Methods A total of 125 pa-tients with spinal fracture combined with spinal cord injury admitted to the Spinal Surgery Department,Affiliated Qingdao Central Hos-pital of Qingdao University from May 2021 to May 2022 were selected as spinal cord injury group.According to the severity,they were divid-ed into complete spinal cord injury group(n=42)and incomplete spi-nal cord injury group(n=83).Meantime,118 patients with simple spi-nal fracture were regarded as the control group.The levels of serum Ghrelin and CTRP3 were measured by enzyme-linked immunosor-bent assay(ELISA).Pearson method was applied to analyze the corre-lation between the expression levels of serum Ghrelin and CTRP3.ROC curve analysis of the prognostic value of Ghrelin and CTRP3 in patients with spinal fracture complicated with spinal cord injury.Results Compared with control group,serum Ghrelin and CTRP3 levels in SCI group were significantly decreased(P＜0.05).Compared with control group,Ghrelin and CTRP3 levels in incomplete SCI group and complete SCI group were significantly decreased(P＜0.05);Compared with the incomplete SCI group,the levels of Ghrelin and CTRP3 in the complete SCI group were significantly decreased(P＜0.05).Correlation analysis showed that there was a positive cor-relation between the levels of Ghrelin and CTRP3 in serum of patients with spinal fracture and SCI(r=0.429,P＜0.001).Compared with the good prognosis group,the levels of Ghrelin and CTRP3 in the poor prognosis group were obviously lower(P＜0.05).The ROC curve analysis results showed that the AUC value of the combined evaluation of serum Ghrelin and CTRP3 for the prognosis of patients with spinal fracture complicated with SCI was higher than that of the independent evaluation of each index(P＜0.001).Conclusion The expression of Ghrelin and CTRP3 in serum of patients with spinal fracture and SCI is low,and the two factors are related to the se-verity of SCI and can be used as potential prognostic markers for spinal fracture complicated with SCI.
spinal fracture combined with spinal cord injuryGhrelinC1q tumor necrosis factor related protein 3prognosis
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