Advances in the involvement of Ras signaling pathway in regulating cell apoptosis
Apoptosis is an active cell death caused by pre-existing cell death processes triggered by both in vivo and in vitro factors,which maintains the stability of the internal environment by clearing aging and damaged cells.Apoptosis plays an important role in both physiological and pathological states,and is regulated by multiple signaling pathways within the cell,affecting the expres-sion of intracellular substances.At present,it is known that the Ras signaling pathway is not only widely involved in regulating multiple physiological and pathological processes such as cell growth,proliferation,differentiation,and apoptosis,but also has the effect of pro-moting autophagic cell death.However,the specific mechanism by which it participates in regulating cell apoptosis has not been fully elucidated.The paper reviews from the molecular mechanism of cell apoptosis,focusing on the mitochondrial apoptosis pathway,death receptor apoptosis pathway,endoplasmic reticulum stress apoptosis pathway related apoptosis pathways and the advances of Ras signal-ing pathway in regulating cell apoptosis.
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