Research progress of neuronal autophagy in post-traumatic stress disorder
Post-traumatic stress disorder(PTSD)is a stress-inducedmental illness with high incidence and difficulty in cur-ing.Severe cases can cause damagein social functioning.Clinical treatment of PTSD is mainly based on drug intervention and psycho-logical counseling,which has large side effects and unsustainable effects.As a way to maintain homeostasis,autophagy plays an impor-tant role in a variety of diseases.Among them,hippocampal neurons in PTSD patients are damaged and contain a large number of au-tophagic lysosomes,which may be related to the onset of PTSD.This article takes the perspective of neuronal autophagy as a starting point and reviews the brain areas and pathogenesis related to PTSD,hoping to provide new directions for research on the pathogenesis of PTSD and new ideas for seeking safe and effective therapeutic targets.
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