摘要
创伤后应激障碍(PTSD)是一种应激性精神疾病,具有发病率高,难治愈的特点,病情严重者能够造成社会功能损害.临床治疗PTSD以药物干预和心理疏导为主,不良作用较大,疗效不持续.自噬作为维持内环境稳态的一种方式,在多种疾病中发挥重要作用,其中PTSD患者海马神经元受损,内有大量自噬溶酶体,可能与PTSD发病有关.文章以神经元自噬角度作为出发点,从PTSD发生相关脑区、发病机制等方面进行综述,以期为PTSD发病机制研究提供新方向,为寻求安全有效治疗靶点提供新思路.
Abstract
Post-traumatic stress disorder(PTSD)is a stress-inducedmental illness with high incidence and difficulty in cur-ing.Severe cases can cause damagein social functioning.Clinical treatment of PTSD is mainly based on drug intervention and psycho-logical counseling,which has large side effects and unsustainable effects.As a way to maintain homeostasis,autophagy plays an impor-tant role in a variety of diseases.Among them,hippocampal neurons in PTSD patients are damaged and contain a large number of au-tophagic lysosomes,which may be related to the onset of PTSD.This article takes the perspective of neuronal autophagy as a starting point and reviews the brain areas and pathogenesis related to PTSD,hoping to provide new directions for research on the pathogenesis of PTSD and new ideas for seeking safe and effective therapeutic targets.
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