Research progress on the correlation between brain-derived neurotrophic factor and depression treatment
Depression is one of the most common mental diseases in clinic,with a high mortality and disability rate,which seri-ously affects patients'quality of life.In recent years,the research on the treatment of depression has been deepened,and it has been found that the level of brain-derived neurotrophic factor(BDNF)in the hippocampus and peripheral blood of patients with major de-pression is reduced.BDNF is a key factor regulating the development and function of neural circuits,and is an important molecule in-volved in neuronal differentiation and growth,synaptic formation and plasticity,and maintaining the structure and function of brain neu-rons.It plays an important role in the occurrence of many neurodegenerative diseases and the study of related drug action mechanisms.BDNF is also becoming an important biomarker in research for the treatment of depression.This article reviews the biological function of BDNF,the relationship between BDNF and depression,and the correlation between BDNF and depression treatment.
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