Prediction value of video electroencephalogram combined with neuron-specific enolase in premature in-fants with brain injury
Objective To explore the prediction value of video electroencephalogram(EEG)combined with neuron-specific enolase(NSE)in premature infants with brain injury.Methods The clinical data of 100 premature infants admitted to Xingtai Peo-ple's Hospital from April 2022 to April 2023 were retrospectively analyzed.All premature infants were divided into brain injury group(n=40)and non-injury group(n=60)using the results of brain magnetic resonance imaging(MRI)as the gold standard.The clinical data of the two groups were compared.All premature infants were examined by video EEG on day 7 and serum NSE at the second day 2 and the seventh day.ROC curve was used to analyze the diagnostic efficacy of video EEG,NSE and their combination in predicting brain injury in premature infants.Results The diagnostic accuracy of video EEG for brain injury in premature infants was 85.00%(85/100),the sensitivity was 77.78%(35/45),the specificity was 90.91%(50/55),and the consistency measure(Kappa)was 0.694.At the second and seventh day of birth,NSE of the brain injury group was significantly higher than that of the non-injury group(P<0.05).ROC curve analysis showed that the best cut-off value of NSE was 20.35 ng/ml,the sensitivity was 75.00%,the specificity was 85.00%,and the AUC was 0.827.The diagnostic efficacy of video EEG combined with NSE was better,and the AUC value,sensitivity and specificity were 90.00%,91.70%and 0.917 respectively,which was better than that of the the two alone,and the difference was statis-tically significant(P<0.05).Conclusion Video EEG combined with NSE has better diagnostic efficacy in predicting brain injury in premature infants.
video EEGneuron specific enolasepremature infantsbrain injurydiagnostic efficiency
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