Current clinical application of intravenous immunoglobulin in neurological disorders
Objective This study aims to investigate and analyze the current usage status of intravenous immunoglobulin(IVIg)in neurology inpatients at a specific hospital,with the goal of promoting the clinical rational application of IVIg.Methods A retrospective study was conducted on neurology inpatients treated with IVIg from June 2021 to September 2023 at the hospital.Pa-tient demographics,disease diagnosis,medication treatment,adverse drug reactions,and disease outcomes were extracted.The ratio-nality of IVIg usage was evaluated based on drug instructions and disease treatment guidelines.Results A total of 110 cases were included in the study,with 70 males(63.64%)and 40 females(36.36%),and 19(17.27%)required intensive care.IVIg was used to treat 15 different diseases,with Guillain-Barre syndrome,myasthenia gravis,and optic neuritis and its spectrum disorders ranking as the top three,accounting for 44.55%of all cases.The overall effective rate of IVIg treatment for neurological disorders was 71.82%,and the incidence of adverse reactions was 5.45%,most of which were transient response.The clinical use of IVIg for off-label indica-tions was common,with 7 cases(6.36%)lacking medical evidence.Inadequate dosage or treatment courses of IVIg were observed in 8 cases(7.27%).2 cases(1.82%)had no flushing of IVIg infusion sets and inappropriate flushing solution were selected in 21 cases(19.09%).Conclusion The proportion of off-label use of IVIg in neurological disorders exceeded 90%.There were some issues such as using lack of evidence,inappropriate usage and dosage,and non-standard use process.Further efforts are needed to strengthen the clin-ical rational application and management of IVIg.
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