Research progress of female reproductive system organoids
In recent years,the global infertility rate has been rising every year,and the society is facing the severe challenge of population crisis and fertility decline,among which the female reproductive system diseases have an impact on fertility that cannot be ignored.Organoids have the ability of self-renewal,self-organization and long-term proliferation,which can simulate the organ-specific gene expression characteristics and reproduce the morphology,structure and function of the original organs.It is an important means to study cell niche and cell interaction,and can accurately simulate the occurrence and development process of tumors,infections and oth-er diseases in the reproductive system,and is a powerful tool for the study of female reproductive system diseases.It opens up a new perspective for exploring the developmental process of female reproductive system and the developmental mechanism of related diseas-es.This article reviews the construction technology and development status of organoids of ovary,fallopian tube,endometrium,cervix and vagina.
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