Advances in the pathogenesis of psoriasis isomorphism
The pathogenesis of psoriasis,which is a common inflammatory skin disease,is still unclear.The psoriasis isomor-phism,also known as Koebner phenomenon(KP),is one of the important clinical features of psoriasis.The current study indicates that the pathogenesis of KP in psoriasis may implicate the involvement of relevant inflammatory mediators(e.g.,chemokines,antimicrobial peptides,tryptase),abnormalities in the proliferation and differentiation of Keratinocytes(KCs),the role of mechanical transduction pathways,and the increased expression of vascular endothelial growth factor(VEGF).The paper reviewed the pathogenesis of KP in psoriasis from the perspectives of immune mediation,abnormal proliferation and differentiation of KCs,vascular proliferation,mechani-cal transduction,and genetic mechanisms.
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