Advances in mild hypothermia-regulated miRNAs in hepatic ischaemia-reperfusion injury
Hepatic ischemia-reperfusion injury(HIRI)is a common complication that cannot be avoided in liver surgery,which can lead to liver failure or even develop into systemic multi-system organ failure.So how to mitigate HIRI has become an urgent problem.The pathogenesis of HIRI is complex and involves a multifactorial combination that can lead to inflammation,oxidative stress,and necrosis and apoptosis of hepatocytes.Mild hypothermia,as a clinically well-established physiotherapeutic treatment,has been shown in vivo and in vitro experiments to mitigate HIRI through the regulation of inflammatory response,oxidative stress,apopto-sis,autophagy,and other processes.Among them,liver-specific miRNAs can be directly regulated by mild hypothermia and play an im-portant role in HIRI by up-regulating or down-regulating the relevant miRNAs to alleviate or exacerbate HIRI,which is one of the key points to mitigate HIRI by mild hypothermia.The paper reviews the mechanism of mild hypothermia and miRNA to mitigate HIRI in re-cent years,as well as the advances in the mild hypothermia to regulate miRNA to mitigate HIRI.
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