浅低温调控miRNA在肝脏缺血再灌注损伤中的研究进展
Advances in mild hypothermia-regulated miRNAs in hepatic ischaemia-reperfusion injury
韦丽娟 1陶品月1
作者信息
- 1. 530007 南宁,广西医科大学第二附属医院麻醉科
- 折叠
摘要
肝脏缺血再灌注损伤(HIRI)是肝脏外科手术中是无法避免的常见并发症,会导致肝脏功能衰竭甚至发展成全身多系统器官功能衰竭,因此如何减轻HIRI成为了亟待解决的问题.HIRI的发病机制复杂,涉及多因素共同作用,可导致炎症、氧化应激反应以及肝细胞的坏死、凋亡.浅低温作为临床上应用成熟的物理治疗方法,已在体内外实验中被证实可以通过调控炎症反应、氧化应激、凋亡、自噬等过程减轻HIRI.其中肝脏特异性的miRNA可直接受浅低温调控,通过上调或下调相关的miRNA减轻或加重HIRI,在HIRI中发挥重要作用,是浅低温改善HIRI的关键点之一.文章就近年来浅低温、miRNA改善HIRI的作用机制以及浅低温调控miRNA改善HIRI的研究进展进行综述.
Abstract
Hepatic ischemia-reperfusion injury(HIRI)is a common complication that cannot be avoided in liver surgery,which can lead to liver failure or even develop into systemic multi-system organ failure.So how to mitigate HIRI has become an urgent problem.The pathogenesis of HIRI is complex and involves a multifactorial combination that can lead to inflammation,oxidative stress,and necrosis and apoptosis of hepatocytes.Mild hypothermia,as a clinically well-established physiotherapeutic treatment,has been shown in vivo and in vitro experiments to mitigate HIRI through the regulation of inflammatory response,oxidative stress,apopto-sis,autophagy,and other processes.Among them,liver-specific miRNAs can be directly regulated by mild hypothermia and play an im-portant role in HIRI by up-regulating or down-regulating the relevant miRNAs to alleviate or exacerbate HIRI,which is one of the key points to mitigate HIRI by mild hypothermia.The paper reviews the mechanism of mild hypothermia and miRNA to mitigate HIRI in re-cent years,as well as the advances in the mild hypothermia to regulate miRNA to mitigate HIRI.
关键词
miRNA/浅低温/缺血再灌注损伤Key words
miRNA/mild hypothermia/ischemia-reperfusion injury引用本文复制引用
基金项目
中华护理学会立项科研课题(2023)(ZHKYQ202318)
广西壮族自治区研究生教育创新计划(YCSW2023250)
出版年
2024
NETL
NSTL
万方数据