Advances in the interaction between pancreatic cancer and macrophages through exosomes
Exosomes are small vesicles secreted by various cells,capable of transmitting through extracellular fluids to influ-ence the physiological and pathological processes of recipient cells.Macrophages,integral to the immune system,also play a vital role in the tumor microenvironment.In the tumor growth,metastasis,and immune evasion of pancreatic cancer,both exosomes and tumor-as-sociated macrophages are the indispensable components.The paper focuses on the interaction of exosomes secreted by pancreatic can-cer cells and macrophages.It provides a comprehensive review of the role and mechanisms of exosomes in the development of pancreat-ic cancer,including the regulatory effects of tumor-derived exosomes on macrophages and the influence of macrophage-derived exo-somes on pancreatic cancer cells.
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