ZIC5 mainly exists in the nucleus and plays a crucial role in the development of the human nervous system as a tran-scription factor or cofactor involved in gene transcription regulatios.Studies have shown that the expression of ZIC5 is abnormally ele-vated in many tumors,and it mediates the development process of tumors,including tumor proliferation and invasion.Understanding the role of ZIC5 in tumors and its internal mechanism will have a guiding effect on the development of novel drugs targeting tumors.The paper reviews the specific role of ZIC5 in tumor,aiming at providing new methods for tumor treatment.
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