Research progress on the relationship between intestinal flora and immunity in traumatic central nervous system injury
After traumatic central nervous system injury,intestinal flora changes disturb the balance of brain-gut axis,trigger-ing abnormal immune inflammatory cascade and aggravating secondary injury.Recent research has found that reducing neuroinflamma-tion caused by traumatic central nervous system injury through immunotherapy,thereby promoting neurological function recovery,is a promising treatment option,and gut flora may be one of the therapeutic targets.This article mainly reviews the mechanism by which in-testinal flora and its metabolites tryptophan,short-chain fatty acids,lipopolysaccharides and peptidoglycans regulate the immune re-sponse after trauma and affect neuroinflammation by regulating lymphocytes and glial cells,and summarizes and prospects the current clinical research status in this field,with a view to developing new therapeutic targets and rehabilitation strategies for these diseases.
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