肠道菌群与创伤性中枢神经系统损伤免疫相关研究进展
Research progress on the relationship between intestinal flora and immunity in traumatic central nervous system injury
尚文雅 1黄靖 1任亚锋2
作者信息
- 1. 450000 郑州,河南中医药大学康复医学院
- 2. 450000 郑州,河南中医药大学第一附属医院康复中心
- 折叠
摘要
创伤性中枢神经系统损伤后,肠道菌群变化扰乱了脑-肠轴的平衡,引发机体异常的免疫炎症级联反应,加重继发性损伤.最新研究发现,通过免疫治疗减少创伤性中枢神经系统损伤引起的神经炎症,从而促进神经功能恢复是一种有前景的治疗方案,而肠道菌群可能是治疗靶点之一.文章主要就肠道菌群及其代谢产物色氨酸、短链脂肪酸、脂多糖、肽聚糖通过调节淋巴细胞、神经胶质细胞调控创伤后的免疫应答,影响神经炎症的作用机制进行综述,并对该领域临床研究现状进行总结与展望,以期为该类疾病开发新的治疗靶点和康复策略.
Abstract
After traumatic central nervous system injury,intestinal flora changes disturb the balance of brain-gut axis,trigger-ing abnormal immune inflammatory cascade and aggravating secondary injury.Recent research has found that reducing neuroinflamma-tion caused by traumatic central nervous system injury through immunotherapy,thereby promoting neurological function recovery,is a promising treatment option,and gut flora may be one of the therapeutic targets.This article mainly reviews the mechanism by which in-testinal flora and its metabolites tryptophan,short-chain fatty acids,lipopolysaccharides and peptidoglycans regulate the immune re-sponse after trauma and affect neuroinflammation by regulating lymphocytes and glial cells,and summarizes and prospects the current clinical research status in this field,with a view to developing new therapeutic targets and rehabilitation strategies for these diseases.
关键词
创伤性脑损伤/脊髓损伤/肠道菌群/免疫/神经炎症Key words
traumatic brain injury/spinal cord injury/gut microbiota/immunity/neuroinflammation引用本文复制引用
基金项目
河南省中医药科学研究专项基金(2022JDZX015)
河南省中医药科学研究专项基金(2021JDZY022)
河南省"双一流"创建学科中医学科学研究专项基金(HSRP-DFCTCM-2023-1-25)
出版年
2024
NETL
NSTL
万方数据