The pathogenesis and treatment progress of exploring Parkinson's disease based on the theory of"microbi-al-brain-gut axis"
Parkinson's disease(PD)is more common in the elderly,and with the gradual progression of the disease,the motor function and non-motor function of PD patients are greatly affected.At present,the main treatment for PD is drug therapy,but long-term use will cause adverse reactions,so it is necessary to find safer and more effective treatment methods.The microbial-brain-gut axis(MGBA)is a pathway connecting the central nervous system and the digestive system,and plays an important role in the pathogenesis of PD.This article mainly reviews the effects of intestinal flora,brain-intestinal peptide and hypothalamic-pituitary-adrenal axis on PD,and the current treatment status of PD based on MGBA theory.
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