基于"微生物-脑-肠轴"理论探讨帕金森的发病机制及治疗进展
The pathogenesis and treatment progress of exploring Parkinson's disease based on the theory of"microbi-al-brain-gut axis"
赵雨欣 1王亚辉 1李杰 1邢军1
作者信息
- 1. 050000 石家庄,河北医科大学第一医院康复科
- 折叠
摘要
帕金森病(PD)多发于老年人群,随着病情逐渐进展,对PD患者的运动功能和非运动功能影响巨大.目前PD的主要治疗是药物治疗,但长期服用会产生不良反应,寻找更安全有效的治疗方法十分必要.微生物-脑-肠轴(MGBA)是连接中枢神经系统与消化系统的通道,在PD发病机制中发挥重要作用.文章主要就肠道菌群、脑肠肽和下丘脑-垂体-肾上腺轴对PD的影响,以及基于MGBA理论对PD的治疗现状等进行综述.
Abstract
Parkinson's disease(PD)is more common in the elderly,and with the gradual progression of the disease,the motor function and non-motor function of PD patients are greatly affected.At present,the main treatment for PD is drug therapy,but long-term use will cause adverse reactions,so it is necessary to find safer and more effective treatment methods.The microbial-brain-gut axis(MGBA)is a pathway connecting the central nervous system and the digestive system,and plays an important role in the pathogenesis of PD.This article mainly reviews the effects of intestinal flora,brain-intestinal peptide and hypothalamic-pituitary-adrenal axis on PD,and the current treatment status of PD based on MGBA theory.
关键词
帕金森/微生物-脑-肠轴/肠道微生物/针刺/神经调控技术/益生菌/粪菌移植Key words
Parkinson's disease/microbial-gut-brain axis/enteric microorganisms/acupuncture/neurore-gulatory tech-niques/probiotics/fecal microbiota transplantation引用本文复制引用
基金项目
河北省中医药管理局2022年度中医药类科研计划课题(Z2022016)
出版年
2024
NETL
NSTL
万方数据