Research progress on SIRT1 in exercise therapy for depression
It has been proved that exercise has positive value in improving depression.Silent information regulator 1(SIRT1),as a histone deacetylase,is involved in the regulation of cell proliferation,aging,apoptosis,DNA repair and other life processes,and its genetic variation is closely related to the pathological mechanism of depression.Its gene variation is closely related to the pathological mechanism of depression,which may be a potential target for the treatment of depression.Currently,some literature points out that SIRT1 may be a potential target for the exercise treatment for depression.Therefore,this article reviews the mechanism of SIRT1 in reg-ulating exercise to improve depression.
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