Advances in the prevention and treatment of allergic diseases by inhibiting the binding of IgE to FcεRⅠ re-ceptor on mast cell
Allergic diseases are one of the most widespread chronic diseases in the world.Mast cells are the most predominant end-effector cells of type I allergic reaction.The binding of IgE to its high affinity receptor FcεRⅠon the surface of mast cells is a key step to initiate the cascade reaction of mast cell to release inflammatory mediators.Blocking or inhibiting the cross-linking of IgE-FcεRI on hypertrophic cell membrane to affect mast cell activation has become an effective strategy and research focus for the preven-tion and treatment of allergic diseases.This article reviews the strategies and related mechanisms of targeting IgE and FεRⅠon mast cells to prevent allergic diseases from three aspects:blocking IgE antibody,IgE-FεRⅠbinding and FεRⅠreceptor.
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