Expressions and clinical correlation of miR-637,miR-223-3p and PARP14 in thyroid cancer
Objective To investigate the expressions of miR-637,miR-223-3p and PARP14 in thyroid cancer and their corre-lation with clinical features.Methods This study selected 73 patients with thyroid cancer from May 2018 to May 2020 at Hengshui People's Hospital.The expressions of miR-637,miR-223-3p and PARP14 in cancerous and adjacent non-cancerous tissues were de-tected by PCR.All patients were followed up for 3 years and divided into death and survival groups based on their survival status.The relationship between expressions of miR-637,miR-223-3p and PARP14 in cancerous tissues and the prognosis,as well as their predic-tive value for prognosis,was analyzed.Results The expressions of miR-637 in thyroid cancerous tissues was lower than that in adjacent non-cancerous tissues,while the expressions of miR-223-3p and PARP14 were higher(P＜0.05).The expressions of miR-637 mRNA was lower in patients with clinical stage Ⅲ to Ⅳ,capsular invasion and lymph node metastasis(P＜0.05).The expressions of PARP14 was higher in patients with clinical stage Ⅲ to Ⅳ,tumor diameter ≥2cm,capsular invasion and lymph node metastasis(P＜0.05).The ex-pressions of miR-223-3p was higher in patients with tumor diameter ≥2cm,capsular invasion and lymph node metastasis(P＜0.05).The expressions of miR-637 in the cancerous tissues of the death group was lower than that of the survival group,while the expressions of miR-223-3p and PARP14 were higher(P＜0.05).Multivariate Cox regression showed that an increased expression of miR-637 in cancerous tissues was a risk factor for the prognosis of patients with thyroid cancer,while the increased expressions of miR-223-3p and PARP14 were protective factors(P＜0.05).The combined detection of miR-637,miR-223-3p and PARP14 expression in cancerous tis-sues had a greater Area Under Curve(AUC)value in predicting the prognosis of patients with thyroid cancer than the individual detec-tion of each marker(P＜0.05).Patients with low miR-637 expressions in cancerous tissues had a lower cumulative survival rate than those of patients with high expressions(P＜0.05);patients with high expressions of miR-223-3p and PARP14 in cancerous tissues had a lower cumulative survival rate than those of patients with low expressions(P＜0.05).Conclusion Abnormal expressions of miR-637,miR-223-3p and PARP14 were observed in the cancerous tissues of patients with thyroid cancer.The expressions of these mark-ers correlated with clinical stages,tumor diameter,lymph node metastasis,and other clinical features and prognosis.Furthermore,the combination of miR-637,miR-223-3p and PARP14 can be used to assess patient prognosis.
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