Effects of Esmolol on inflammatory factors and serum miR-29a and GDF-15 in patients with acute anteri-or ST-segment elevation myocardial infarction after PCI
Objective To explore the therapeutic effect of Esmolol in patients with acute anterior ST-segment elevation myo-cardial infarction after percutaneous coronary intervention(PCI),as well as the effects on inflammatory factors and serum miR-29a and GDF-15.Methods A total of 120 patients with acute anterior ST-segment elevation myocardial infarction who underwent PCI in Xinxiang Central Hospital from April 2021 to June 2023 were prospectively selected as the study objects,and were divided into the study group(60 cases)and the control group(60 cases)according to random number table method.The control group was given con-ventional treatment,and the study group was combined with Esmolol injection on the basis of the control group for 24 hours.The safety,cardiac function indexes,inflammatory factor levels,myocardial en-zyme indexes,miR-29a and GDF-15 were compared between the two groups.Results There was no significant difference in the inci-dence of symptomatic hypotension,symptomatic bradycardia and ma-lignant arrhythmia between the two groups(P＞0.05).After 1 week of treatment,left ventricular ejection fraction increased compared with before treatment,while left ventricular end-systolic volume index,left ventricular end-diastolic diameter and BNP decreased compared with before treatment(P＜0.05).After 1 week of treatment,the changes of left ventricular ejection fraction,left ventricular end-systolic vol-ume index,left ventricular end-diastolic inner diameter and BNP in the study group were better than those in the control group(P＜0.05).After 1 week of treatment,CRP,myeloperoxidase,IL-6,CK-MB and cTnⅠ were all decreased compared with those before treatment(P＜0.05).After 1 week of treatment,CRP,myeloperoxidase,L-6 and cTnⅠ in the study group were lower than those in the control group(P＜0.05).The results of repeated measurement ANOVA showed that miR-29a and GDF-15 were decreased in both groups after treat-ment compared with before treatment,and miR-29a and GDF-15 were lower after 1 week than after 3 days of treatment(P＜0.05).But miR-29a and GDF-15 in the study group were superior to those in the control group after 3 days and 1 week of treatment(P＜0.05).Conclusion Esmolol has a good therapeutic effect on patients with acute anterior ST-segment elevation myocardial infarction after PCI,which can effectively improve cardiac function,reduce inflammatory factors,alleviate myocardial injury,regulate serum miR-29a and GDF-15 levels,and does not increase the risk of adverse reactions.
acute anterior ST elevation myocardial infarctionpercutaneous coronary interventionesmololsafetyinflamma-tory factorsmiR-29aGDF-15
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