Research progress on the mechanism of intestinal flora in chronic pain
The intestinal tract is known as the second brain of the human being,and intestinal flora has an impact on the brain through the gut-brain axis,and is involved in the regulation of many diseases,including Alzheimer's disease,Parkinson's disease,chronic pain and depression.Previous studies have shown that intestinal flora can regulate pain development,but its mechanism of ac-tion in patients with chronic pain remains unclear.This article mainly reviewed the mechanism of intestinal flora regulation of chronic pain,discussed the brain changes caused by intestinal flora imbalance from different pain models,and the possibility of treating chron-ic pain through targeted intervention of intestinal flora.
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