Research progress of outer membrane vesicles derived from Klebsiella pneumoniae
Klebsiella pneumoniae is a typical conditional pathogen of the Enterobacteriaceae family and a member of the six super bacteria known as"ESKAPE.It usually colonizes the human respiratory tract and intestines and can cause a variety of infections including pneumonia,meningitis and bloodstream infections,etc.Outer membrane vesicles(OMV)are biologically active vesicle-like structures secreted spontaneously by Gram-negative bacteria,which contain polysaccharides,outer membrane proteins and nucleic ac-ids.Current studies have confirmed that OMVs derived from Klebsiella pneumoniae play an important role in pathogenic mechanism,transmission of effectors and interaction with the host.Therefore,this review focuses on the basic information,biological functions and biomedical applications of OMVs derived from Klebsiella pneumoniae,and the related latest research progress.
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