肠黏膜屏障功能客观评价指标的研究和应用现状
Research and current applications of objective indicators for the assessment of intestinal mucosal barrier function
王艳磊 1赵宇 1袁海硕 1靳君华1
作者信息
- 1. 010050 呼和浩特,内蒙古医科大学附属医院肝胆胰脾外科
- 折叠
摘要
肠黏膜屏障能够阻止肠道内致病菌及有害物质进入机体,同时作为防御屏障抵御外界环境的变化,逐渐引起临床重视,由于其参与多种疾病的发病机制,现已成为研究热点.目前,临床通过测定D-乳酸、内毒素等指标变化,间接反映肠黏膜屏障功能受损情况,但部分指标对肠道的损伤严重程度缺少具体的定量标准,且临床患者病因复杂,病情轻重各异,因此急需特异、敏感、可定量的评价指标辅助评估肠黏膜屏障受损情况.文章就目前在临床开展的和处于基础研究阶段并有望应用于临床的评价指标进行综述,为后期肠黏膜屏障功能的精确诊断提供理论依据.
Abstract
The intestinal mucosal barrier can prevent pathogenic bacteria and harmful substances from entering the body,and be a defensive shield against changes in the external environment.This function has increasingly gained clinical attention due to its in-volvement in the pathogenesis of various diseases,positioning it as a focal point of research.At present,clinical assessments indirectly reflect impairments in intestinal mucosal barrier function by measuring changes in indicators such as D-lactic acid and endotoxins.However,some of these indicators lack specific quantitative standards for assessing the severity of intestinal damage.Furthermore,the etiology of clinical patients is complex and the conditions vary significantly in severity.Therefore,there is an urgent need for specific,sensitive and quantifiable evaluation indicators to aid in assessing the impairment of intestinal mucosal barrier.This article provided a comprehensive review of evaluation indicators that are currently in clinical use or in the basic research stage with potential clinical ap-plications,aiming to provide a theoretical basis for the precise diagnosis of intestinal mucosal barrier function in later stages.
关键词
肠黏膜屏障/评价指标/研究进展Key words
intestinal mucosal barrier/evaluation index/research progress引用本文复制引用
基金项目
内蒙古医科大学基础医学院"育才"计划重点实验室开放基金(NYFZBL202208)
内蒙古医科大学联合项目(YKD2023LH037)
出版年
2024
NETL
NSTL
万方数据