Research and current applications of objective indicators for the assessment of intestinal mucosal barrier function
The intestinal mucosal barrier can prevent pathogenic bacteria and harmful substances from entering the body,and be a defensive shield against changes in the external environment.This function has increasingly gained clinical attention due to its in-volvement in the pathogenesis of various diseases,positioning it as a focal point of research.At present,clinical assessments indirectly reflect impairments in intestinal mucosal barrier function by measuring changes in indicators such as D-lactic acid and endotoxins.However,some of these indicators lack specific quantitative standards for assessing the severity of intestinal damage.Furthermore,the etiology of clinical patients is complex and the conditions vary significantly in severity.Therefore,there is an urgent need for specific,sensitive and quantifiable evaluation indicators to aid in assessing the impairment of intestinal mucosal barrier.This article provided a comprehensive review of evaluation indicators that are currently in clinical use or in the basic research stage with potential clinical ap-plications,aiming to provide a theoretical basis for the precise diagnosis of intestinal mucosal barrier function in later stages.
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