Effects of sepsis on cognitive behavior in young male CD-1 mice
Objective To investigate the cognitive impairment and its recovery in young male CD-1 mice after cecal ligation and perforation(CLP).Methods A number of CD-1 male mice aged 7～8 weeks were modeled respectively,and CLP group and sham operation group(Sham group)were set up.After successful modeling,the surviving Sham and CLP mice were fed until the 10th,10th,20th,30th and 60th day after surgery for radial six-arm water maze(RAWM)and object position re-recognition,respectively.Results Compared with Sham group,the number of learning errors and latency of RAWM in CLP mice within 30 days after surgery were higher than those in Sham group(P＜0.05),but there was no significant difference at 60 days after surgery(P＞0.05).The num-ber of RAWM memory errors and latency of CLP mice within 60 days after operation were significantly higher than those of Sham group(P＜0.05).In the object position re-recognition experiment,the new position preference index of 10 min delay and 24 h delay of CLP mice were lower than those of Sham group at 10 and 20 days after op-eration(P＜0.05).There were no significant differences in the new position preference index of 10 min delay and 24 h delay at 30 and 60 days after surgery compared with Sham group(P＞0.05).Conclu-sion Young CD-1 male mice still had significant spatial memory im-pairment at 60 days after CLP surgery,and RAWM was a more sensi-tive evaluation method.
sepsiscecal ligation and puncturecognitionbehaviormice
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