Research progress of ferroptosis targeting tumor stemness
Tumor stemness plays a critical role in tumor growth,metastasis and drug resistance.In clinical treatment,the ulti-mate goal is to reduce tumor stemness to improve the survival rate of cancer patients.Ferroptosis is a novel form of procedural cell death,which can be triggered by tumor cell ferroptosis to target tumor stem cells,thereby inhibiting tumor stemness,slowing tumor pro-gression,and reducing chemotherapy resistance.This article mainly reviews the principle and influencing factors of the targeted regula-tion of tumor stemness by ferroptosis.
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