Antibiotic bone cement spacer in the treatment of deep wound infection after spinal internal fixation
Objective This study was aimed to observe the clinical efficacy of antibiotic bone cement in the treatment of in-fection after spinal internal fixation.Methods A retrospective analysis was made of the 25 patients with infection after spinal inter-nal fixation who had been treated at our hospital from March 2015 to December 2023.Antibiotic bone cement was implanted after radi-caldebridement in 10 of them(cement group),but was not in 15 of them(no-cement group).The times of debridement,wound healing,36 concise health status survey(SF-36)scores and internal fixation retention were compared.Results The infection was cured in the cement group with one-time debridement.Internal fixation was removed in 2 cases and retained in the other 8 cases.The wounds of 9 cases healed within 2 weeks after debridement,and 1 case could not heal because of exposure of bone cement spacer and healed after the operation of removing bone cement.In the no-cement group,8 cases were cured after one-time debridement,and the other 7 cas-es needed multiple debridement.Internal fixation was removed in 5 cases and retained in the other 10 cases.In the last follow-up Physi-cal Component Score(PCS)and the Mental Component Score(MCS)of the cement group were higher than that of the no-cement group(P＜0.05).Conclusion Antibiotic bone cement exclu-sion is an effective method for the treatment of wound infection af-ter spinal internal fixation.It not only reduces the dead space,but also achieves the purpose of local targeted drug delivery.
spinal internal fixationantibiotic bone cementsurgical site infectionpolymethyl methacrylate
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