BTKI adverse reaction evaluation:Research and analysis based on FAERS database
Objective To explore the new adverse reactions and provide the basis for the selection and safety for the individu-ally clinical plans.Methods Relevant information was extracted from the FAERS database from the fourth quarter of 2013 to the third quarter of 2023,and the adverse events of three BTK inhibitors were analyzed using the disproportionality analysis.In this study,the reporting odds ratio method and MHRA were used to identify signals.Results Ibrutinib has strong AE signals in ear and labyrin-thine diseases,Zanubrutinib has strong AE signals in skin and subcutaneous tissue diseases,Acalabrutinib has strong AE signals in blood and lymphatic system diseases,and some adverse events not mentioned in the instructions were found.Conclusion The ad-verse reactions of BTK inhibition have certain commonalities,but each has its own characteristics.Individualized drug selection and monitoring should be based on the patient's physiological status during the selection and medication period.
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