Research progress of O-GlcNAcylation modification in kidney diseases
O-GlcNAcylation(O-linked n-acetylglucosamine glycosylation)modification is one of the common protein post-translational modifications,involving the addition of O-linked β-n-acetylglucosamine(O-GlcNAc)to serine/threonine residues on pro-teins,and plays an important role in various cellular processes,including metabolism,signal transduction and apoptosis.Abnormal modification of O-GlcNAcylation is closely related to the occurrence of many diseases,including cancer,diabetes,cardiovascular dis-eases and neurodegenerative diseases.Recent studies have shown that the protein O-GlcNAcylation modification is also widely in-volved in the occurrence and development of kidney diseases.Therefore,in order to understand the changes of O-GlcNAc modification in common kidney diseases,this paper reviews the studies of O-GlcNAcylation modification in diseases related to kidney(embryonic)development,gene mutation or abnormal kidney development.It provides reference for further study of perturbation of O-GlcNAcyla-tion modification in kidney diseases and development of specific therapeutic methods based on this target.
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