GPNMB:New opportunities in the diagnosis and treatment of triple-negative breast cancer
Triple-negative breast cancer(TNBC)is a molecular subtype of breast cancer with poor prognosis and limited treat-ment options.However,its high expression of glycoprotein non metastatic melanoma protein B(GPNMB)provides a biological basis for molecular diagnosis and antibody-drug conjugate therapy targeting this protein.This article reviews the biological characteristics of GPNMB and the related studies on diagnosis and treatment targeting this protein.
triple-negative breast cancerantibody-drug conjugatesglycoprotein non-metastatic melanoma protein B
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