Research progress on the treatment and its mechanism of postpartum depression with Esketamine
Postpartum depression is a common mental disorder in postpartum women,which can affect their postpartum emo-tions and even lead to suicidal or infanticide behaviors.However,the commonly used drugs for treating postpartum depression in clini-cal practice have disadvantages such as high treatment failure rate,slow onset and high cost.There is an urgent need for drugs that can take effect quickly and have high safety.Numerous clinical studies show that Esketamine has rapid antidepressant and anti-suicidal ef-fects.In 2019,the US Food and Drug Administration(FDA)approved the dextroisomer of ketamine,Esketamine,as a treatment option for refractory depression,which has also attracted attention in the prevention and treatment of postpartum depression.The paper re-views the application and mechanism of Esketamine in the treatment of postpartum depression based on relevant domestic and foreign literature,aiming to provide new ideas for the prevention and treatment of postpartum depression patients.
Esketaminepostpartum depressionmechanismclinical research
NETL
NSTL
万方数据
