Study on changes of injury condition and thyroid hormone level after abdominal explosion injury in high altitude environment
Objective To establish an animal model of abdominal explosive injury in a hypobaric hypoxic environment at high-altitude,and explore the effects and trends of high-altitude environment on vital signs and thyroid hormones after abdominal explo-sive injury,and explore the relevant mechanisms.Methods 24 healthy goats were randomly divided into two groups(n=12):high-altitude explosive injury group(about 4700 m above sea level)and plain explosive injury group(about 800 m above sea level).The two groups of experimental goat were placed in the field at the corresponding heights for explosion induced injury.The survival and gross anatomy of experimental goat in each group were observed and com-pared for 12 h.Vital signs were monitored and recorded at the corre-sponding time points,venous blood was drawn,and serum thyroid hor-mone levels were detected.Results The amount of ascites in the high-altitude explosion injury group was higher than that in the plain explosion injury group(P<0.05).At 2 h,8 h,10 h,and 12 h,the systol-ic blood pressure of the high-altitude explosion injury group was high-er than that of the plain explosion injury group(P<0.05).At 8 h,10 h,and 12 h,the diastolic blood pressure of the high-altitude explosion injury group was higher than that of the plain explosion injury group (P<0.05).At 8 h,10 h,and 12 h,the heart rate of the high-altitude explosion injury group was higher than that of the plain explosion in-jury group(P<0.05).At 8 h and 10h,the body temperature of the high-altitude explosion injury group was higher than that of the plain explosion injury group(P<0.05).At 6 h,8 h,10 h,and 12 h,the T3 level in the high-altitude explosion injury group was higher than that in the plain explosion injury group(P<0.05).At all time points(except for 2 h and 6 h),the FT3 level in the high-altitude explosion injury group was higher than that in the plain explosion injury group(P<0.05).At 8 h,10 h,and 12 h,the FT4 level in the high-altitude explosion injury group was higher than that in the plain explosion injury group(P<0.05).At 6 h,8 h,10 h,and 12 h,the TSH levels in the high-altitude explosion injury group were lower than those in the plain explosion injury group(P<0.05).Conclusion The high-altitude environment can significantly aggravate the degree of abdominal explosive injury,and can affect the secretion of thyroid hor-mones after abdominal explosive injury by adjusting the HPT axis,accelerating the dynamic changes of thyroid hormones after explo-sive injury.
high altitudehypobaric hypoxiacoldabdominal explosive injurythyroid hormone
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