Predictive value of serum Aβ1-42,CXCL16 and VILIP-1 in combination for cognitive impairment in Par-kinson's disease patients
Objective To explore the predictive value of serum amyloid β-protein 1-42(Aβ1-42),CXC chemokine ligand 16 (CXCL16),and visinin like protein 1(VILIP-1)in combination for cognitive impairment in patients with Parkinson's disease(PD).Methods A total of 81 PD patients(n=81)admitted to the Neurology Department of Yulin Red Cross Hospital from December 2021 to December 2022 were selected as the PD group,and 81 healthy individuals(n=81)undergoing physical examinations during the same period were selected as the control group.The PD patients were further divided into a normal cognitive group(≥26 points,n=44) and a cognitive impairment group(<26 points,n=37)based on the Montreal Cognitive Assessment(MoCA)scores.Serum levels of Aβ 1-42,CXCL16 and VILIP-1 were determined by enzyme-linked immu-nosorbent assay(ELISA).The factors affecting cognitive impairment in PD patients were analyzed by logistic regression.The predictive val-ue of serum Aβ1-42,CXCL16,and VILIP-1 for cognitive impairment in PD patients was analyzed by Receiver Operating Characteristic (ROC) curves.Results Compared to the control group,the PD group had significantly lower serum Aβ1-42 levels(P<0.05)and sig-nificantly higher levels of CXCL16 and VILIP-1(P<0.05).Compared to the normal cognitive group,the cognitive impairment group had sig-nificantly lower serum Aβ1-42 levels(P<0.05)and significantly high-er levels of CXCL16 and VILIP-1(P<0.05).Multivariate logistic regression analysis showed that Aβ1-42 is a protective factor against cognitive impairment in PD patients(P<0.05),while CXCL16 and VILIP-1 are risk factors(P<0.05).ROC analysis showed that the combined prediction of serum Aβ1-42,CXCL16,and VILIP-1 had the highest AUC for predicting cognitive impairment in PD patients,significantly outperforming individual predictions by Aβ1-42,CXCL16,and VILIP-1 (Z triple combination-Aβ1-42=2.056,P=0.040,Z triple combination-CXCL16=2.716,P=0.007,Z triple combination-VILIP-1=2.394,P=0.017).Conclusion Sserum levels of Aβ1-42 are significantly de-creased,while CXCL16 and VILIP-1 levels are significantly increased in PD patients.The combination of these three markers can bet-ter predict the occurrence of cognitive impairment.
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