Therapeutic efficacy analysis of varying dosages of bone cement filling in the treatment of Kummell's disease
Objective To compare the postoperative efficacy of different doses of bone cement injection in patients with Kum-mell's disease and explore the potential benefits of intensified bone cement dose therapy for these patients.Methods A retrospec-tive analysis was conducted on 59 patients with Kummell's disease treated at our hospital from May 2021 to June 2023.Binary logistic regression analysis was employed to assess the correlation between bone cement dose and postoperative pain relief.Receiver operating characteristic curve(ROC)analysis was further utilized to determine the recommended value for bone cement injection dose.Patients were divided into two groups according to the recommended value:a conventional-dose group(3.0 to 5.5 mL of bone cement)and a high-dose group(5.6 to 9.0 mL of bone cement).Pain relief,vertebral height recovery,kyphosis Cobb Angle change,and rate of bone cement leakage were evaluated before and after surgery.Results Binary logistic regression analysis revealed a significant correla-tion between the injection dose of bone cement and postoperative pain relief (OR=2.93,95％CI 1.48-5.82,P=0.002).ROC curve analysis demonstrated an area under curve (AUC) value of 0.740 (95％CI 0.610-0.870),and the bone cement dose corresponding to the maxi-mum Jorden index was 5.5 mL.The VAS score,ODI score,vertebral height,and Cobb Angle significantly improved after surgery in both groups (P<0.05).Additionally,the high-dose bone cement injection group exhibited significantly better recovery rates for vertebral height improvement,VAS score reduction,and ODI score improvement com-pared to the conventional dose group(P<0.05).Conclusion In patients with Kummell's disease,when the dosage of bone cement injection exceeds 5.5 mL,there is an improved clinical efficacy without an increased likelihood of postoperative bone cement leakage.
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