Association of pregnancy weight gain,blood lipid levels and macrosomia in non-diabetic pregnancies
Objective This study is aimed to study the relationship between pregnancy weight gain,blood lipid levels and non-diabetic macrosomia in single pregnant women.Methods 255 non-diabetic pregnant women who delivered in our hospital from June 2022 to June 2023 were enrolled and were divided into macrosomia group(55 cases)and non-macrosomia group(200 cases)ac-cording to newborn birth weight.Demographic information and clinical data were recorded.Univariate and multivariate logistic regres-sion were used to analyze to the risk factors of macrosomia.The ROC curve was used to evaluate the predictive ability of the model and calculate cut-off points.Results The incidence of macrosomia was 21.57％.The gestational age,weight gain and triglycerides(TG) of macrosomia group were significantly higher than those in the non-macrosomia group,while low-density lipoprotein cholesterol(LDL-C)was lower than that in the non-macrosomia group(P<0.05).Gestational age(OR=1.417,95％CI:1.020-1.967),weight gain during pregnancy(OR=1.095,95％CI:1.027-1.168)and triglycerides(OR=1.570,95％CI:1.231-2.001)were independent risk factors for non-diabetic macrosomia.The ROC curve showed that weight gain>18.75 kg and TG>3.645 mmol/L could be used as a predictor of non-diabetic macrosomia(P<0.05).AUC area,sensitivity and specificity were 0.714,63.6％,73.5％,respectively.Conclusion The occurrence of non-diabetic macrosomia is related to excessive weight gain and high triglyceride level during pregnancy.The combined detec-tion has high predictive value.TG levels in the third trimester is help-ful to detect occult macrosomia and control pregnancy weight gain rea-sonably,thereby improving perinatal outcomes.
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