水凝胶载药系统在骨肉瘤治疗中的研究进展
Advances on hydrogel drug delivery systems in the treatment of osteosarcoma
李志朋 1章磊 1黎承军1
作者信息
- 1. 210002南京,南京大学医学院附属金陵医院(东部战区总医院)骨科
- 折叠
摘要
骨肉瘤是儿童和青少年最常见的原发性恶性骨肿瘤,具有高度侵袭性,易在短时间内发生肺或全身转移,且复发率高,预后差.骨肉瘤的系统和规范治疗方案包括新辅助化疗、手术和术后放化疗.由于缺乏骨靶向性,传统的化疗药物往往不能在骨肉瘤部位积累,因此必须使用大剂量药物,进而不可避免地导致相关的全身不良反应.通过水凝胶载药系统进行局部给药,能够有效增高局部药物浓度、延长药物滞留时间、降低全身不良反应、减少给药频率、改善患者依从性.文章主要就近年来水凝胶载药系统在骨肉瘤治疗中的应用进行综述.
Abstract
Osteosarcoma is the most common primary malignant bone tumor in children and adolescents,characterized by high invasiveness,rapid progression to pulmonary or systemic metastasis within a short period,high recurrence rates and poor prognosis.The systematic and standardized treatment regimen for osteosarcoma includes neoadjuvant chemotherapy,surgery,and postoperative radio-therapy and chemotherapy.Due to the lack of bone targeting,traditional chemotherapy drugs often cannot accumulate at the site of osteo-sarcoma,necessitating the use of high-dose medications,which inevitably leads to related systemic adverse reactions.Local administra-tion through hydrogel drug delivery systems can effectively increase local drug concentration,prolong drug retention time,reduce sys-temic adverse reactions,decrease frequency of administration,and improve patient compliance.This paper mainly reviews the applica-tion of hydrogel drug delivery systems in the treatment of osteosarcoma in recent years.
关键词
骨肉瘤/水凝胶/载药系统Key words
osteosarcoma/hydrogel/drug delivery systems引用本文复制引用
出版年
2024
NETL
NSTL
万方数据