Role of NLRP3 inflammasome in hepatic fibrosis induced by hepatic stellate cell activation
Persistent inflammation and the activation of hepatic stellate cells(HSCs)are major factors in the development of hepatic fibrosis.Inflammation induces the release of inflammatory factors from cells,which enhances immune function,regulates body temperature,and inhibits the proliferation of cancerous cells,etc.However,persistent and repeated inflammatory responses will cause hepatic fibrosis.Among the family of inflammasomes,NLRP3 inflammasome has increasingly demonstrated an important role in the pathogenesis of hepatic fibrosis,and in particular,NLRP3 inflammasome can exacerbate hepatic fibrosis by inducing the activation of HSCs.Therefore,the mechanism of the role of NLRP3 inflammasome in the activation of HSCs and the therapeutic perspectives are fo-cused in this review.
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