Objective To explore the clinical value of tissue motion annular displacement in quantitative evaluation of left ventricular systolic function in patients with chronic kidney disease.Methods 30 patients with CKD were collected according to the 2017 Guidelines for the Screening,Diagnosis and Prevention of chronic kidney disease in China,and 35 healthy subjects were selected as the control group.Four sites of mitral annular motion displacement from the apical four-chamber and two-chamber view were obtained by two dimensional speckle tracking imaging,and the overall longitudinal strain and overall circum-ferential strain of the left ventricle were obtained simultaneously.Linear correlation was used to analyze the relationship between TMAD parameters and left ventricular ejection fraction and golbal longitudinal strain.ROC curve was drawn to predict the effi-ciency of TAMD parameters in diagnosing subclinical reduced left ventricular systolic function in patients with CKD.Results Compared with the control group,IVST,PWT and LVMI were increased in CKD group(P<0.05).The measured value of T-AP4sep,T-AP4lat,T-AP4mid,T-AP4mid％,T-AP2int,T-AP2ant,T-AP2mid,T-AP2mid％,mTAMDmid and mTMADmid％decreased(P<0.05).T-AP4mid,mTMADmid and mTMADMmid％were positively correlated with LVEF(r=0.522,r=0.475,r= 0.413,P<0.05)and T-AP4mid,T-AP2mid,mTMADmid and mTMADMmid％were negatively correlated with GLS(r=-0.584,r=-0.430,r=-0.558,r=-0.620,P<0.01).mTMADmid％(AUC,0.93,with sensitivity of 87％,specificity of 95％,and cut-off value of 11.9％was better for predicting reduced left ventricular systolic function in patients with CKD.Conclusion TMAD can quantita-tively evaluate the left ventricular systolic function in patients with chronic kidney disease at an early stage with good repeatability.
维普
万方数据