Objective To investigate the correlation between the severity and rate of progression of cerebral white matter hy-perintensities(WMH)and serum homocysteine(Hcy)levels in healthy physical examiners.Method Cranial MR images and laboratory data of 1251 cases of health checkups were selected.The volume of periventricular white matter hyperintensity(PVWMH)and deep white matter hyperintensity(DWMH)and the proportion of the two to the total brain white matter volume,respectively were counted in cranial MRI T2-FLAIR images using the United Imaging Intelligence(UII)brain white matter high signal tool.271 equivalent data from 1251 subjects who had been examined in 2017 were also selected for longitudinal compari-son with the 2021 data.Linear regression models were used to analyze the relationship between Hcy serum levels and the severity(for cross-sectional comparisons)and rate of progression(for longitudinal comparisons)of PVWMH and DWMH.Results Cross-sectional analysis showed that serum homocysteine levels were associated with PVWMH volume(P=0.038,β=0.056)and PVWMH volume share(P=0.023,β=0.61)but not DWMH volume or volume share,while longitudinal analysis showed that se-rum homocysteine baseline levels were not associated with PVWMH and DWMH volume progression(P>0.05).Conclusion In healthy subjects,serum homocysteine level was correlated only with the severity of PVWMH and did not independently pre-dict the progression of PVWMH and DWMH.
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