摘要
目的 探讨基于体素内不相干运动扩散加权成像(IVIM-DWI)及增强T1mapping序列的定量参数在预测肺癌化疗疗效中的作用.方法 选取 52 例经病理确诊并至少完成两个周期化疗的晚期肺癌患者资料,根据治疗效果分为化疗敏感组与不敏感组.化疗前均行IVIM-DWI及增强T1mapping序列检查,测量、计算化疗敏感组与不敏感组病变的D值、D* 值、f值、增强T1mapping的各参数值(T1pre、T1post、ΔT1%)及细胞外体积(ECV)分数,并进行统计学分析,采用受试者工作特征曲线(ROC曲线)评估各参数预测肺癌化疗疗效的效能.结果 敏感组治疗前T1post明显低于不敏感组(t =-4.96,P<0.001),ΔT1%及ECV分数明显高于不敏感组(t=5.40,P<0.001;t=5.64,P<0.001).ROC曲线结果显示ECV分数在肺癌化疗疗效预测中的AUC最高(AUC=0.880).ECV分数与T1post或ΔT1%之间的AUC没有明显差异.D、D*、f、T1pre 两组间比较,差异无统计学意义(P>0.05).结论 敏感组通常比不敏感组有更低的T1post值、更高的ΔT1%值和ECV分数,T1post、ΔT1%和ECV分数对化疗前预测晚期肺癌疗效具有一定作用.
Abstract
Objective To investigate the role of quantitative parameters obtained based on intravoxel incoherent motion-diffusion weighted imaging(IVIM-DWI)and enhanced T1mapping sequences in predicting the chemotherapy efficacy in lung cancer.Methods Fifty-two patients with advanced lung cancer who were diagnosed by pathology and had completed at least two cycles of chemotherapy in our hospital were selected and divided into a treatment-sensitive group and an insensitive group ac-cording to their treatment effects.Patients underwent IVIM-DWI and enhanced T1mapping sequences prior to treatment,and D,D*,f values,values of enhanced T1mapping parameters(T1pre,T1post,ΔT1%),and extracellular volume(ECV)fraction were measured and calculated.Statistical analysis was performed.Results The T1post values of pre-treatment lesions in the sensitive group were significantly lower than those in the insensitive group(t=-4.96,P<0.001),and the ΔT1%and ECV fractions of pre-treatment lesions were significantly higher than those in the insensitive group(t=5.40,P<0.001;t=5.64,P<0.001).The ROC curves showed that ECV fractions had the highest AUC in predicting chemotherapy efficacy in lung cancer(AUC=0.880),and there was no significant difference in AUC between ECV fractions and T1post or ΔT1%.D,D*,f,and T1pre showed no statisti-cally significant differences between the two groups(P>0.05).Conclusion T1post,ΔT1%and ECV fraction have a role in pre-dicting the efficacy of advanced lung cancer before chemotherapy,and the sensitive group usually has lower T1post values,higher ΔT1%values and ECV fraction than the insensitive group.
基金项目
山东省自然科学基金面上项目(ZR2021MH216)
维普
万方数据